期刊
CANCER LETTERS
卷 376, 期 2, 页码 303-309出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2016.03.046
关键词
Mutant p53; Cancer; Secretome; Microenvironment; Cytokines
类别
资金
- Italian Association for Cancer Research (AIRC) [12182]
- Joint Projects program from University of Verona [B12I15002320003]
An ever-increasing number of studies highlight the role of mutant p53 proteins in the alteration of cancer cell secretome and in the modification of tumour microenvironment, sustaining an invasive phenotype of cancer cell. The knowledge of the molecular mechanisms underlying the interplay between mutant p53 proteins and the microenvironment is becoming fundamental for the identification of both efficient anticancer therapeutic strategies and novel serum biomarkers. In this review, we summarize the novel findings concerning the regulation of secreted molecules by cancer cells bearing mutant TP53 gene. In particular, we highlight data from available literature, suggesting that mutant p53 proteins are able to (i) alter the secretion of enzymes involved in the modulation of extracellular matrix components; (ii) alter the secretion of inflammatory cytokines; (iii) increase the extracellular acidification; and (iv) regulate the crosstalk between cancer and stromal cells. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
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