期刊
CANCER LETTERS
卷 373, 期 2, 页码 156-163出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2016.01.004
关键词
IL-11; Cancer; Cytokine; Immune response
类别
资金
- Des Moines University [IOER 05-14-01, IOER 112-3749, IOER 112-3114]
Interleukin-11 (IL-11) is a member of the glycoprotein-130 (GP-130) cytokines that utilizes the GP-130 signaling pathway shared by other cytokines of the same family. Traditionally regarded as an anti-inflammatory cytokine, IL-11 also demonstrates its role as a proinflammatory cytokine, suggesting its complex role in immune response. In recent years, IL-11 has an emerging role in various inflammation associated cancers. In this review, we aim to discuss IL-11 signaling pathway, to explore the role of IL 11 in immunity and various cancers, and to provide a therapeutic perspective of strategies utilized to interfere IL-11 signaling in cancer cells. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
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