期刊
CANCER LETTERS
卷 373, 期 1, 页码 19-26出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2016.01.022
关键词
Atg4 protease; Autophagy; Atg8/LC3; Apoptosis; Targeted cancer therapy
类别
资金
- National 973 Basic Research Program of China [2013CB911300]
- National Natural Science Foundation of China [81402496, 81473091]
Atg4 proteases are cysteine proteases, which are well known for their crucial roles in the lipidation and delipidation of LC3 during the autophagy process. At least four human Atg4 homologs have been reported according to their sequence homology to the yeast Saccharomyces cerevisiae (Sc) Atg4. Accumulating evidence has recently indicated that abnormal expression levels of some human Atg4 proteins occur in several types of cancer cells, which may be closely related to tumor progression, tumor suppression and cancer therapy resistance. In this review, we focus on highlighting the pivotal roles of the human Atg4 proteases in the LC3 conjugation system and their major function in autophagy. Moreover, we further explore the roles of human Atg4 proteases as potential novel targets for cancer therapy. Taken together, these findings would shed light on elucidating the key roles of Atg4 proteases from autophagy modulation to targeted cancer therapy. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
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