期刊
TRENDS IN PLANT SCIENCE
卷 25, 期 5, 页码 446-454出版社
CELL PRESS
DOI: 10.1016/j.tplants.2020.01.010
关键词
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资金
- National Natural Science Foundation of China [31521001, 91854103, 31661143025, 31900382]
- Beijing Short-Term Recruitment Program of Foreign Experts
- Chinese Academy of Sciences President's International Fellowship Initiative [2018VBA0025]
- China Postdoctoral Science Foundation [2018M641518]
In photosynthetic cells, chloroplasts and mitochondria are the sites of the core redox reactions underpinning energy metabolism. Such reactions generate reactive oxygen species (ROS) when oxygen is partially reduced. ROS signaling leads to responses by cells which enable them to adjust to changes in redox status. Recent studies in Arabidopsis thaliana reveal that chloroplast NADH can be used to generate malate which is exported to the mitochondrion where its oxidation regenerates NADH. Oxidation of this NADH produces mitochondrial ROS (mROS) which can activate signaling systems to modulate energy metabolism, and in certain cases can lead to programmed cell death (PCD). We propose the term 'malate circulation' to describe such redistribution of reducing equivalents to mediate energy homeostasis in the cell.
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