期刊
TRENDS IN NEUROSCIENCES
卷 43, 期 4, 页码 227-241出版社
CELL PRESS
DOI: 10.1016/j.tins.2020.01.009
关键词
-
资金
- NIMH [R01 MH113545]
Genes that are mutated in Autism Spectrum Disorders (ASD) can be classified broadly as either synaptic or developmental. But what if this is a false distinction? A recent spate of publications has provided evidence for developmental mechanisms that rely on neural activity for proper cortical development. Conversely, a growing body of evidence indicates a role for developmental mechanisms, particularly chromatin remodeling, during learning or in response to neural activity. Here, we review these recent publications and propose a model in which genes that confer ASD risk operate in signal transduction networks critical for both cortical development and synaptic homeostasis.
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