期刊
TRENDS IN NEUROSCIENCES
卷 43, 期 3, 页码 144-154出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tins.2020.01.003
关键词
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资金
- NIMH [R01 MH119349]
- Pew Charitable Trusts
- Burroughs Wellcome Fund
Healthy central nervous system (CNS) development and function require an intricate and balanced bidirectional communication between neurons and glia cells. In this review, we discuss the complementary roles of astrocytes and microglia in building the brain, including in the formation and refinement of synapses. We discuss recent evidence demonstrating how these interactions are coordinated in the transition from healthy physiology towards disease and discuss known and potential molecular mechanisms that mediate this cellular crosstalk.
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