期刊
TRENDS IN MICROBIOLOGY
卷 28, 期 6, 页码 465-477出版社
CELL PRESS
DOI: 10.1016/j.tim.2019.12.007
关键词
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资金
- Medical Research Council - Raymond and Beverly Sackler Fund
- Royal Society [109385/Z/15/Z]
- Wellcome Trust [109385/Z/15/Z]
- UKRI [ES/S000186/, MR/P007201/1, MR/N002660/1]
- UK Research and Innovation Fellowship [MR/S00291X/1]
- Wellcome Trust [109385/Z/15/Z] Funding Source: Wellcome Trust
- MRC [MR/P007201/1, 1933099, MR/N002660/1, MR/S00291X/1] Funding Source: UKRI
Staphylococcus aureus is an important human bacterial pathogen that has a cosmopolitan host range, including livestock, companion and wild animal species. Genomic and epidemiological studies show that S. aureus has jumped between host species many times over its evolutionary history. These jumps have involved the dynamic gain and loss of host-specific adaptive genes, usually located on mobile genetic elements. The same functional elements are often consistently gained in jumps into a particular species. Further sampling of diverse animal species is likely to uncover an even broader host range and greater genetic diversity of S. aureus than is already known, and understanding S. aureus host specificity in these hosts will mitigate the risks of emergent human and livestock strains.
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