期刊
TRENDS IN IMMUNOLOGY
卷 41, 期 1, 页码 17-28出版社
CELL PRESS
DOI: 10.1016/j.it.2019.11.004
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资金
- Associazione Italiana per la Ricerca sul Cancro (AIRC) [20607]
- National Institute of Allergy and Infectious Diseases (NIAID) [5R01-AI114442]
- American Lebanese Syrian Associated Charities (ALSAC)
- ASSISI Foundation of Memphis
- Immune Tolerance Network (ITN)
- AIRC
CD8(+) T cell immunological memory of past antigen exposure can confer long-lived protection against infections or tumors. The fact that CD8(+) memory T cells can have features of both naive and effector cells has forced the field to struggle with several conceptual questions about the developmental origin of the cell and, consequently, the mechanism(s) that contribute to memory development. Here, we discuss recent conceptual advances in our understanding of memory T cell development that incorporate data describing a hybrid stem and/or effector state of differentiation. We theorize that the mechanisms invoked in developing these cells could be mediated, in part, through epigenetic programs. Finally, we consider the potential therapeutic implications of inducing and/or utilizing such hybrid cells clinically.
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