期刊
TRENDS IN IMMUNOLOGY
卷 41, 期 1, 页码 46-60出版社
CELL PRESS
DOI: 10.1016/j.it.2019.11.006
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资金
- AGAUR of the Catalan Government (Generalitat de Catalunya) [2017SGR149]
- Ministerio de Economia y Competitividad (MINECO) [SAF2017-87990-R]
- Spanish Ministry of Science, Innovation, and Universities (MICINN) [RTI2018-094788-A-I00]
- La Caixa Banking Foundation [LCF/BQ/PI19/11690001, HR17-00247]
- Ministerio de Ciencia, Innovacion y Universidades (MCNU) [SAF2016-75511-R]
- National Program for Doctoral Training (FPI) [ES-2014-069525]
- Instituto de Salud Carlos III (ISCIII)
- MCNU
- Pro CNIC Foundation
- Severo Ochoa Center of Excellence [SEV-2015-0505]
B lymphopoiesis is tightly regulated at the level of gene transcription. In recent years, investigators have shed light on the transcription factor networks and the epigenetic machinery involved at all differentiation steps of mammalian B cell development. During terminal differentiation, B cells undergo dramatic changes in gene transcriptional programs to generate germinal center E cells, plasma cells and memory B cells. Recent evidence indicates that mature B cell formation in volves an essential contribution from 3D chromatin conformations through its interplay with transcription factors and epigenetic machinery. Here, we provide an up-to-date overview of the coordination between transcription factors, epigenetic changes, and chromatin architecture during terminal B cell differentiation, focusing on recent discoveries and technical advances for studying 3D chromatin structures.
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