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Introns: Good Day Junk Is Bad Day Treasure

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TRENDS IN GENETICS
卷 35, 期 12, 页码 923-934

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ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tig.2019.09.010

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  1. Canadian Institute of Health Research (CIHR)
  2. Research Chair in RNA Biology and Cancer Genomics

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Introns are ubiquitous in eukaryotic transcripts. They are often viewed as junk RNA but the huge energetic burden of transcribing, removing, and degrading them suggests a significant evolutionary advantage. Ostensibly, an intron functions within the host pre-mRNA to regulate its splicing, transport, and degradation. However, recent studies have revealed an entirely new class of trans-acting functions where the presence of intronic RNA in the cell impacts the expression of other genes in trans. Here, we review possible new mechanisms of intron functions, with a focus on the role of yeast introns in regulating the cell growth response to starvation.

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