期刊
TRENDS IN GENETICS
卷 35, 期 12, 页码 923-934出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tig.2019.09.010
关键词
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资金
- Canadian Institute of Health Research (CIHR)
- Research Chair in RNA Biology and Cancer Genomics
Introns are ubiquitous in eukaryotic transcripts. They are often viewed as junk RNA but the huge energetic burden of transcribing, removing, and degrading them suggests a significant evolutionary advantage. Ostensibly, an intron functions within the host pre-mRNA to regulate its splicing, transport, and degradation. However, recent studies have revealed an entirely new class of trans-acting functions where the presence of intronic RNA in the cell impacts the expression of other genes in trans. Here, we review possible new mechanisms of intron functions, with a focus on the role of yeast introns in regulating the cell growth response to starvation.
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