期刊
TRENDS IN ENDOCRINOLOGY AND METABOLISM
卷 30, 期 12, 页码 903-914出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tem.2019.08.006
关键词
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资金
- Hubei Science and Technology Support Project [2018BEC473]
- Major Research Plan of the National Natural Science Foundation of China [91639304, 91729303]
- National Science Fund for Distinguished Young Scholars [81425005]
- National Science Foundation of China [81870171, 81570271]
In parallel with the obesity epidemic, nonalcoholic fatty liver disease (NAFLD) has emerged as the most common chronic liver disease worldwide. Disequilibrium of lipid metabolism and the subsequent metabolic-stress-induced inflammation are believed to be central in the pathogenesis of NAFLD. Of note, metabolic inflammation is primarily mediated by innate immune signaling, which is increasingly recognized as a driving force in NAFLD progression. Currently, a series of agents targeting one or more of these pathomechanisms have shown encouraging results in preclinical models and clinical trials. This review summarizes the emerging molecular tar gets involved in signaling in the lipid metabolism and innate immunity aspects of NAFLD, focusing on their mechanistic roles and translational potentials.
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