期刊
TRENDS IN CELL BIOLOGY
卷 30, 期 3, 页码 189-200出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2019.12.009
关键词
-
类别
资金
- Vlaams Instituut voor Biotechnologie (VIB)
- Ghent University
- Fonds voor Wetenschappelijk Onderzoek Vlaanderen (FWO) [G013715N, G044518N, EOS MODEL-IDI 30826052]
- Flemish Government [BOF09/01M00709, BOF16/MET_V/007]
- FWO
The serine/threonine kinase RIPK1 has emerged as a crucial component of the inflammatory response activated downstream of several immune receptors, where it paradoxically functions as a scaffold to protect the cell from death or instead as an active kinase to promote the killing of the cell. While RIPK1 kinase-dependent cell death has revealed its physiological importance in the context of microbial infection, aberrant activation of RIPK1 is also demonstrated to promote cell death-driven inflammatory pathologies, highlighting the importance of fundamentally understanding proper RIPK1 regulation. Recent advances in the field demonstrated the crucial role of phosphorylation in the fine-tuning of RIPK1 activation and, additionally, question the exact mechanism by which RIPK1 enzymatic activity transmits the death signal.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据