期刊
TRENDS IN CELL BIOLOGY
卷 29, 期 12, 页码 964-973出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2019.09.002
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资金
- National Institutes of Health (NIH) National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) [R01AR068286]
- NIH National Institute on Aging (NIA) [R01AG059605]
- Pew Charitable Trusts
- NIH National Heart, Lung, and Blood Institute (NHLBI) [T32HL007752]
Cell fusion is essential for the development of multicellular organisms, and plays a key role in the formation of various cell types and tissues. Recent findings have highlighted the varied protein machinery that drives plasma-membrane merger in different systems, which is characterized by diverse structural and functional elements. We highlight the discovery and activities of several key sets of fusion proteins that together offer an evolving perspective on cell membrane fusion. We also emphasize recent discoveries in vertebrate myoblast fusion in skeletal muscle, which is composed of numerous multinucleated myofibers formed by the fusion of progenitor cells during development.
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