期刊
TRENDS IN BIOTECHNOLOGY
卷 38, 期 8, 页码 888-906出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibtech.2020.01.001
关键词
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资金
- National Key Research and Development Program of China [2017YFC1600403, 2017YFC1600405]
- National Outstanding Youth Foundation [21822806]
- National Natural Science Foundation of China [31670095, 31770097]
- Fundamental Research Funds for the Central Universities [JUSRP51701A]
- Distinguished Professor Project of Jiangsu Province
- National First-Class Discipline Program of Light Industry Technology and Engineering [LITE2018-08]
- 111 Project [111-2-06]
Based on the development of automatic devices and rapid assay methods, various high-throughput screening (HTS) strategies have been established for improving the performance of industrial microorganisms. We discuss the most significant factors that can improve HTS efficiency, including the construction of screening libraries with high diversity and the use of new detection methods to expand the search range and highlight target compounds. We also summarize applications of HTS for enhancing the performance of industrial microorganisms. Current challenges and potential improvements to HTS in industrial biotechnology are discussed in the context of rapid developments in synthetic biology, nanotechnology, and artificial intelligence. Rational integration will be an important driving force for constructing more efficient industrial microorganisms with wider applications in biotechnology.
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