期刊
TRENDS IN BIOTECHNOLOGY
卷 38, 期 7, 页码 729-744出版社
CELL PRESS
DOI: 10.1016/j.tibtech.2019.12.008
关键词
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资金
- National Institute of General Medical Sciences of the National Institutes of Health [R35GM128620]
- College of Engineering, University of Georgia, Athens, USA
Proteins found in nature have traditionally been the most frequently used biocatalysts to produce numerous natural products ranging from commodity chemicals to pharmaceuticals. Protein engineering has emerged as a powerful biotechnological toolbox in the development of metabolic engineering, particularly for the biosynthesis of natural products. Recently, protein engineering has become a favored method to improve enzymatic activity, increase enzyme stability, and expand product spectra in natural product biosynthesis. This review summarizes recent advances and typical strategies in protein engineering, highlighting the paramount role of protein engineering in improving and diversifying the biosynthesis of natural products. Future prospects and research directions are also discussed.
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