期刊
TRENDS IN BIOCHEMICAL SCIENCES
卷 45, 期 1, 页码 27-41出版社
CELL PRESS
DOI: 10.1016/j.tibs.2019.09.007
关键词
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资金
- German Cancer Consortium (DKTK)
- DFG [BI 1044/12-1, BI 1044/13-1]
- ANPCyT [PICT PRH-2016-4835, PICT 20163525, PICT 2017-0388]
- FOCEM-Mercosur [COF 03/11]
- CONICET (Argentina)
Protein-protein interactions often regulate the activity of protein kinases by allosterically modulating conformation of the ATP-binding site. Bidirectional allostery implies that reverse modulation (i.e., from the ATP-binding site to the interaction and regulatory sites) must also be possible. Here, we review both the allosteric regulation of protein kinases and recent worl. describing how compounds binding at the ATP-binding site can promote or inhibit protein kinase interactions at regulatory sites via the reverse mechanism. Notably, the pharmaceutical industry has been developing compounds that bind to the ATP-binding site of protein kinases and potently disrupt protein-protein interactions between target protein kinases and their regulatory interacting partners. Learning to modulate allosteric processes will facilitate the development of protein-protein interaction modulators.
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