期刊
TRENDS IN BIOCHEMICAL SCIENCES
卷 45, 期 1, 页码 6-12出版社
CELL PRESS
DOI: 10.1016/j.tibs.2019.10.005
关键词
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资金
- Ministry of Education of China
- National Science Foundation of China (NSFC) [91132718]
- NIH [P01 HL103526]
- Peking-Tsinghua Center for Life Sciences
- Claudia Adams Barr Program for Innovative Cancer Research
- European Research Council (ERC) under a Horizon 2020 MSCA-IF grant [702346]
- Marie Curie Actions (MSCA) [702346] Funding Source: Marie Curie Actions (MSCA)
Netrin is a prototypical axon guidance cue. Structural studies have revealed how netrin interacts with the deleted in colorectal cancer (DCC) receptor, other receptors, and co-factors for signaling. Recently, genetic studies suggested that netrin is involved in neuronal haptotaxis, which requires a reversible adhesion process. Structural data indicate that netrin can also mediate trans-adhesion between apposing cells decorated with its receptors on the condition that the auxiliary guidance cue draxin is present. Here, we propose that netrin is involved inconditional adhesion, a reversible and localized process that can contribute to cell adhesion and migration. We suggest that netrin-mediated adhesion and signaling are linked, and that local environmental factors in the ventricular zone, the floor plate, or other tissues coordinate its function.
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