期刊
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
卷 124, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.trac.2019.115781
关键词
Saliva; Saliva analysis; Saliva sampling methods; Saliva sampling devices; Saliva composition; Salivary biomarkers
资金
- European Union [NMBP-13-2017 KardiaTool, 768686]
The continuous exchange of chemicals with blood and the non-invasive collection make saliva an interesting specimen for clinical applications, from the detection of biomarkers to the new eomic sciences in medicine. However, saliva sampling is challenging because the suitability of the collection method for the analyte of interest is either poorly investigated or, more often, not mentioned at all in most publications. This review reports a critical evaluation of the most common procedures for saliva sampling and a description of the off-the-shelf sampling devices. Their suitability for bioanalytical applications and salivary biomarkers detection, e.g. representativeness of the sample, sampling feasibility, analyte recovery, and sample amount, is discussed. (C) 2019 Elsevier B.V. All rights reserved.
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