期刊
CANCER INVESTIGATION
卷 35, 期 1, 页码 32-35出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/07357907.2016.1253710
关键词
Non-small cell lung cancer; Src; gene expression
类别
资金
- Bristol Myers Squibb
- Department of Veterans Affairs
The Src pathway in activated in about one-third of non-small cell lung cancer (NSCLC) tumors. Dasatinib has Src-inhibitor activity. We examined the activity of dasatinib in 37 patients with advanced, previously treated NSCLC. Among the 29 patients who underwent pre-treatment biopsy for RNA biomarker analysis, 25 were treated with dasatinib 70 mg twice daily. There were no responses. Five patients discontinued treatment due to toxicity. Three patients hadminor biopsy-related pneumothoraces. Given the lack of responses, no biomarkers were analyzed. Dasatinib 70 mg twice daily does not have activity nor is it well tolerated in unselected patients with advanced stage, previously treated NSCLC.
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