期刊
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
卷 123, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.trac.2019.115774
关键词
Chiral stationary phases; Monolith; Post-modification; One-pot approach; Single-step approach; Enantioseparation; Liquid chromatography
资金
- National Natural Science Foundation of China [81503031and 81872832]
- Science and Technology Project of Guangdong Province [2016A020226004, 2019A1515010806]
- Initial Scientific Research Fund of Doctor in Foshan University [gg040952]
- International Science & Technology Cooperation Program of Guangzhou, China [201807010022]
Chiral separation remains a very important topic in different fields of analytical chemistry such as pharmaceutical, agrochemical, environmental and food analysis. Over the last 20 years, various chiral monoliths, based on chiral selectors such as cyclodextrins and their derivatives, polysaccharide derivatives, proteins, antibiotics, chiral ligands, cinchona alkaloids and amino acid derivatives, as well as molecularly imprinted polymers, have been developed for the enantioseparation of a wide range of analytes. The present review summarizes the recent developments of monolithic chiral stationary phases (CSPs) with particular emphasis on their classification and preparation. The major challenges and future prospects of monolithic CSPs are also briefly discussed. (C) 2019 Elsevier B.V. All rights reserved.
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