期刊
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
卷 122, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.trac.2019.115702
关键词
Analyte preconcentration; Capillary electrophoresis; Liquid phase separation; Microreactors; Sample pretreatment
资金
- National Center for Research and Development in Poland [DZP/V4-Korea-I/20/2018]
- National Research Development and Innovation Office of Hungary [K116263, NN127062, 2018-2.1.17-TET-KR-2018-00010]
- Hungarian Government [Bionano_GINOP-2.3.2-15-2016-00017]
- Hungarian Academy of Sciences
- New National Excellence Program of The Ministry for Innovation and Technology [UNKP-19-4]
- European Regional Development Fund-Project SINGING PLANT [CZ.02.1.01/0.0/0.0/16_026/0008446]
- Institute of Analytical Chemistry Czech Academy of Sciences [RVO 68081715]
- National Research Foundation of Korea [NRF-2018K1A3A1A39088119, NRF-2017K1A3A1A67016126, NRF-2016R1A2B2011878]
- Slovak Academy of Sciences [APVV-17-0318, VEGA/1/0787/18, APVV SK-KR-18-0013]
- Project of regional collaboration V4-Korea [MTB 8F17003]
By coupling a sample pretreatment technique of sample clean up and enrichment power with capillary electrophoresis (CE) of high-performance separation, the task of analyzing trace analytes in a complex matrix such as a biological sample can be carried out successfully with ease. This review aims for providing an overview of strategies to couple sample pretreatment techniques with capillary and related microscale (e.g., microchip) electrophoresis, practically adoptable in an automatic manner, without requiring serious modification of existing instruments to install sophisticated interfaces. In-line sample pretreatment techniques based on liquid phase microextraction performed before sample injection and on-line sample preconcentration techniques performed during or after sample injection are discussed with emphasis on the applicability to samples of high conductivity, commonly encountered for biological samples. An overview of the recent developments in microfluidic immobilized enzymatic microreactors which fit excellently to microchip CE is also given. (C) 2019 Elsevier B.V. All rights reserved.
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