期刊
CANCER IMMUNOLOGY IMMUNOTHERAPY
卷 65, 期 2, 页码 181-192出版社
SPRINGER
DOI: 10.1007/s00262-015-1786-1
关键词
Renal cell carcinoma; Memory T cells; Effector T cells; T-box expressed in T cells; Eomesodermin; Natural killer cells
T-box transcription factors, T-box expressed in T cells (T-bet) encoded by Tbx21 and Eomesodermin (Eomes), drive the differentiation of effector/memory T cell lineages and NK cells. The aim of the study was to determine the prognostic influence of the expression of these transcription factors in peripheral blood (pB) in a cohort of 41 metastatic (m) RCC patients before receiving sorafenib treatment and to analyze their association with the immunophenotype in pB. In contrast to Tbx21, in the multivariate analysis including clinical features, Eomes mRNA expression was identified as an independent good prognostic factor for progression-free survival (PFS, p = 0.042) and overall survival (OS, p = 0.001) in addition to a favorable ECOG performance status (p = 0.01 and p = 0.008, respectively). Eomes expression correlated positively not only with expression of Tbx21 and TGF beta 1 mRNA, but also with mRNA expression of the activation marker ICOS, and with in vivo activated HLA-DR+ T cells. Eomes expression was negatively associated with TNF alpha-producing T cells. On protein level, Eomes was mainly expressed by CD56(+)CD3(-) NK cells in pB. In conclusion, we identified a higher Eomes mRNA expression as an independent good prognostic factor for OS and PFS in mRCC patients treated with sorafenib.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据