Chiral iminophosphorane catalyzed asymmetric phenylselenylation of 3-substituted oxindoles

Organocatalyzed asymmetric phenylselenylation of 3-substituted oxindoles was achieved with chiral iminophosphoranes. A wide range of phenylselenylated oxindoles were synthesized in good to excellent yields (80-99%) and up to 97% ee under mild conditions. The procedure feathers simple separation and scale up to semi-gram without loss of enantioselectivity. (C) 2020 Elsevier Ltd. All rights reserved.