Bioactive drimane sesquiterpenoids and isocoumarins from the marine-derived fungus Penicillium minioluteum ZZ1657

Four new compounds, including three drimane sesquiterpenoids purpurides E-G(1-3) and one isocoumarin peniisocoumarin H(4), together with 15 known compounds, were isolated from the marine-sourced fungus Penicillium minioluteum ZZ1657. Their structures were elucidated by a combination of the HRESIMS data, extensive NMR spectroscopic analyses, and single crystal X-ray diffractions. Purpurides E(1) and F(2) are two N-acetyl-L-valine-conjugated drimane sesquiterpenoids and showed antimicrobial activities against methicillin-resistant Staphylococcus aureus, Escherichia coli, and Candida albicans with MIC values of 6-12 and 3-6 mu g/mL, respectively. Purpuride G(3) showed antiproliferative activities against human glioma U251 and U87MG cells with IC50 values of 4.49 and 10.9 mu M, respectively. (C) 2019 Elsevier Ltd. All rights reserved.