期刊
TETRAHEDRON
卷 76, 期 15, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2020.131101
关键词
Thiazole; Ugi reaction; Wittig reaction; isocyano(triphenylphosphoranylidene)acetate; Thiocarboxylic acid
资金
- National Natural Science Foundation of China [21572075]
- 111 Project [B17019]
A new one-pot four-component preparation of polysubstituted thiazoles by a cascade Ugi/Wittig cyclization has been developed. The four-component reactions of the odorless isocyano(triphenylphosphoranylidene)acetates 1, aldehydes 2, amines 3 and thiocarboxylic acids 4 produced 2,4,5-trisubstituted thiazoles 5 in moderate to good yields in the presence of triethylamine. The two-component reactions between isocyano(triphenylphosphoranylidene)acetates 1 and thiocarboxylic acids 4 in the presence of triethylamine provided the corresponding 4,5-disubstituted thiazoles 6 in good yields as well. (C) 2020 Elsevier Ltd. All rights reserved.
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