Palladium-catalyzed aminocarbonylation of 2-phenyimidazo[1,2-a] pyridines using chloroform as carbon monoxide source and their mechanistic studies

The synthesis of Imidazo[1,2-a]pyridine-3-carboxamides has been carried out by aminocarbonylation using chloroform as carbon monoxide surrogate. Reported protocol is simple, efficient, tolerates wide variety of substrates and the products were formed in good yields. The method can be exploited for the functionalisation of wide range of N-heterocycles with medicinal interest. The detailed mechanistic investigation of metal-catalyzed carboxamide preparation using Density Functional Theory (DFT) calculations has also been reported. (C) 2020 Elsevier Ltd. All rights reserved.