期刊
TALANTA
卷 206, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.talanta.2019.120206
关键词
Persistent luminescence; Label-free probe; Near-infrared emission; Hemoglobin detection; Human serum sample
资金
- National Natural Science Foundation of China [21607160, 51872300, U1832110]
- Ningbo Science and Technology Bureau [2016C50009]
- W. C. Wong Education Foundation [rczx0800]
Hemoglobin (Hb) plays an important role in oxygen carriage for mammals, which is also a typical biomarker for certain diseases. Although numerous methods had been developed for the detection of Hb in red blood cells, analytical technology for the monitoring of low-abundance Hb in serum or plasma is still a challenge. Herein, persistent luminescence nanoparticles (PLNPs) with strong near-infrared (NIR) emission character behaving as a label-free probe for the highly sensitive and selective detection of Hb were developed. Further studies revealed that the sensing mechanism should be attributed to the Hb-induced dynamic quenching process. Moreover, the nanoprobe showed high selectivity to Hb against the common existing substances in human serum and a linear response to Hb ranging from 1 to 50 nM with an extremely high limit of detection (LOD) of 0.13 nM. Finally, applicability of the proposed probe for the detection of Hb in human serum samples was validated.
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