期刊
TALANTA
卷 206, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.talanta.2019.120248
关键词
Amphoricarpos autariatus; NMR; FTIR; Metabolomics; Cytotoxic activity; Dry-column flash chromatography
资金
- Ministry of Education and Science of the Republic of Serbia [172053]
Metabolomics generate a profile of small molecules from plant extracts, which could be directly responsible for bioactivity effects. Using thy-column flash chromatography enabled a rapid and inexpensive method for the very efficient separation of plant extract with a high resolution. This separation method coupled to NMR and FTIRbased metabolomics is applied to identify bioactive natural products. OPLS multivariate analysis method, was used for correlation the chemical composition of the plant extracts, Amphoricarpos autariatus, with the results of cytotoxic activity against Human cervical adenocarcinoma cell line (HeLa) and epithelial lung cancer cell line (A549). In this way, the highest contribution to the cytotoxic activity was recorded for the guaianolide sesquiterpene lactones named amphoricarpolides. The compounds indicated as bioactive after metabolomics analysis were tested, and their cytotoxic activity were confirmed.
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