期刊
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
卷 26, 期 5, 页码 692-701出版社
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/1055-9965.EPI-16-0721
关键词
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资金
- National Cancer Institute [CA14002, CA63446, CA77305, CA078682, CA078762, CA078552, CA078802, N01-PC-67000, CA 160607]
- U.S. Department of Defense [DAMD17-96-1-6071]
- California Breast Cancer Research Program [7PB-0068]
- California Department of Public Health [103885]
- National Cancer Institute's Surveillance, Epidemiology and End Results Program [HHSN261201000036C]
- Centers for Disease Control and Prevention's National Program of Cancer Registries [1U58 DP000807-01]
- Utah Cancer Registry
- State of Utah Department of Health
- New Mexico Tumor Registry
- Arizona cancer registry
- Consejo Nacional de Ciencia y Tecnologia (CONACyT) [SALUD-2002-C01-7462]
- Colorado cancer registry
- Centers for Disease Control and Prevention National Program of Cancer Registries
Background: Hispanic women have lower breast cancer incidence rates than non-Hispanic white (NHW) women. To what extent genetic versus nongenetic factors account for this difference is unknown. Methods: Using logistic regression, we evaluated the interactive influences of established risk factors and ethnicity (self-identified and identified by ancestral informative markers) on breast cancer risk among 2,326 Hispanic and 1,854 NHW postmenopausal women from the United States and Mexico in the Breast Cancer Health Disparities Study. Results: The inverse association between the percentage of Native American (NA) ancestry and breast cancer risk was only slightly attenuated after adjusting for known risk factors [lowest versus highest quartile: odds ratio (OR) = 1.39, 95% confidence interval (CI) = 1.00-1.92 among U.S. Hispanics; OR = 1.92 (95% CI, 1.29-2.86) among Mexican women]. The prevalence of several risk factors, as well as the associations with certain factors and breast cancer risk, differed according to genetic admixture. For example, higher body mass index (BMI) was associated with reduced risk among women with lower NA ancestry only [BMI < 25 versus > 30: OR = 0.65 (95% CI, 0.44-0.98) among U.S. Hispanics; OR = 0.53 (95% CI, 0.29-0.97) among Mexicans]. The average number of risk factors among cases was inversely related to the percentage of NA ancestry. Conclusions: The lower NA ancestry groups were more likely to have the established risk factors, with the exception of BMI. Although the majority of factors were associated with risk in the expected directions among all women, BMI had an inverse association among Hispanics with lower NA ancestry. Impact: These data suggest that the established risk factors are less relevant for breast cancer development among women with more NA ancestry. (C) 2016 AACR.
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