期刊
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
卷 26, 期 1, 页码 110-115出版社
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/1055-9965.EPI-16-0451
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资金
- Swedish Council for Working Life and Social Research [20040504, 2007-0224]
- Swedish Research Council [K2008-70X-15366-043]
- Swedish Cancer Society [09 0666]
- Swedish Childhood Cancer Society [PROJ06/050, PROJ09/086]
- Swedish Radiation Protection Authority [SSI P 1572]
- Danish Strategic Research Council [2103-05-0006, 2064-04-0010]
- Swiss Federal Office of Public Health [05.001626]
- Swiss Research Foundation on Mobile Communication [A2006.18]
- Swiss National Science Foundation [PDFMP3_122873]
- Research Council of Norway [175163/V40]
- Swiss National Science Foundation (SNF) [PDFMP3_122873] Funding Source: Swiss National Science Foundation (SNF)
Background: Previous studies have evaluated the effect of medical diagnostic radiation on brain tumors. Recent cohort studies have reported an increased risk associated with exposure to head CT scans. Methods: Information regarding medical conditions, including prenatal and postnatal exposure to medical diagnostic radiation, was obtained from CEFALO, a multicenter case-control study performed in Denmark, Norway, Sweden, and Switzerland through face-to-face interview. Eligible cases of childhood and adolescent brain tumors (CABT) were ages 7 to 19 years, diagnosed between January 1, 2004 and August 31, 2008, and living in the participating countries (n = 352). The cases were matched by age, sex, and region to 646 population-based controls. Results: Prenatal exposure to medical diagnostic radiation and postnatal exposure to X-rays were not associated with CABTs. A higher risk estimate of CABTs, although not statistically significant, was found for exposure to head CT scan (OR, 1.86; 95% confidence interval, 0.82-4.22). The associations with head injury, febrile seizure, fever in the first 12 weeks, and general anesthesia were close to unity. Conclusions: Prenatal or postnatal medical conditions, including medical diagnostic radiation, were not associated with CABTs. On the basis of small numbers of exposed children, we observed a nonsignificant increased risk for CT scans of the head. Impact: We have presented additional evidence, suggesting that exposure to head CT scan may be associated with the occurrence of CABTs. (C)2016 AACR.
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