期刊
CANCER EPIDEMIOLOGY
卷 40, 期 -, 页码 15-21出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.canep.2015.10.026
关键词
World Cancer Research Fund; American Institute for Cancer Research; Pancreatic cancer; Diet; Risk factors
资金
- Fondazione Italiana per la Ricerca sul Cancro (FIRC), Italy
- National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland, USA [KL2 TR000069/UL1TR000067]
- Fondazione Umberto Veronesi Fellowship, Italy
- Associazione Italiana per la Ricerca sul Cancro Funding Source: Custom
Background: Pancreatic cancer is a leading cause of cancer death. A role of dietary factors in pancreatic carcinogenesis has been suggested. The World Cancer Research Fund (WCRF) and the American Institute for Cancer Research (AICR) published 8 recommendations for cancer prevention. We evaluated the effect of adherence to the WCRF/AICR recommendations on pancreatic cancer risk. Methods: We operationalized 7 of the 8 WCRF/AICR recommendations to generate a WCRF/AICR score. We examined the association of WCRF/AICR score with pancreatic cancer in data from an Italian case-control study of 326 incident cases and 652 controls. Results: Adherence to WCRF/AICR recommendations was associated with a significantly decreased risk of pancreatic cancer. Using a WCRF/AICR score <3.5 as a reference, the adjusted odds ratio (OR) for a score 3.5-<4 was 0.80 (95% CI 0.49, 1.28), for a score 4-<5 0.54 (95% CI 0.35, 0.82), and for score 5 or more 0.41 (95% CI 0.24, 0.68; p- value for trend 0.0002). The OR for a continuous increment of one unit of the WCRF/AICR score was 0.72 (95% CI 0.60, 0.87). Conclusion: Adherence to the WCRF/AICR recommendations may reduce pancreatic cancer risk. (C) 2015 Elsevier Ltd. All rights reserved.
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