期刊
STEM CELLS AND DEVELOPMENT
卷 29, 期 9, 页码 555-561出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/scd.2019.0237
关键词
MSCs; mitochondrial dysfunction; mitochondrial transfer; Miro1; TNTs; Cx43; brain ischemia
资金
- Neurosurgery Research Fund, Department of Neurosurgery, School of Medicine, Loma Linda University, Loma Linda, California
Mitochondrial dysfunction is an important pathological process in the setting of ischemic brain injury. Stem cell-mediated mitochondrial transfer provides an efficient intercellular process to supply additional mitochondria in the ischemic brain tissues. In this review, we summarize the mitochondrial pathology associated with brain ischemia, mechanisms of stem cell-mediated mitochondrial transfer, and in vitro/in vivo experimental findings of mitochondrial transfer from stem cells to ischemic vascular endothelial cells/neurons as potential therapeutic strategy in the management of ischemic brain injury.
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