期刊
STEM CELL RESEARCH
卷 44, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.scr.2020.101746
关键词
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资金
- German Center for Cardiovascular Research (DZHK) [81x2300165, 81x2300170]
- Heidenreich von Siebold Program from the University Medical Center Gottingen
- Else Kroner-Fresenius-Stiftung Foundation
- Deutsche Forschungsgemeinschaft [1816]
The Takotsubo syndrome (TTS) is characterized by acute transient left ventricular dysfunction in the absence of obstructive coronary lesions. An enhanced beta-adrenergic signaling and higher sensitivity to catecholamine-induced-toxicity were identified as mechanisms associated with TTS. It is still elusive, whether TTS patients with recurrent events show similar underlying signaling pathomechanism. Induced pluripotent stem cell (iPSC)-lines were generated from skin fibroblasts of two independent female Takotsubo syndrome patients with a severe phenotype characterized by recurrent TTS events. For reprogramming, a non-integrative plasmid technique was used. All generated iPSCs maintained full pluripotency, genomic integrity, and spontaneous in vitro and in vivo differentiation capacity.
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