期刊
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
卷 229, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.saa.2019.117949
关键词
Zinc ions; Point-of-care testing; Paper-based devices; High-throughput; Imaging
类别
资金
- National Natural Science Foundation of China [81672508, 61601218]
- Jiangsu Provincial Foundation for Distinguished Young Scholars [BK20170041]
- Natural Science Foundation of Shaanxi Province [2019JM-016]
- China-Sweden Joint Mobility Project [51811530018]
- Key University Science Research Project of Jiangsu Province [19KJA520005]
- Fundamental Research Funds for the Central Universities
The combination of fluorescence method with paper-based diagnostic device is quite suitable in point-of-care testing (POCT). Herein, we designed a novel hybrid fluorescein-based probe ZN-2 and investigated its fluorescent properties thoroughly in the detection of Zn2+. In comparison with the fluorescein-based probe ZN-1, ZN-2 displayed better sensitivity, long-wavelength and faster response to Zn2+ within 20 min. Interestingly, we could achieve ultrasensitive, high-throughput and visual detection in the POCT analysis of Zn2+ by anchoring this probe ZN-2 on the paper-based device. This device with satisfied performance for Zn2+ detection was achieved in real samples including cytochylema, serum and lake water. Finally, the probe ZN-2 was further applied to visualize and monitor the level changes of Zn2+ in the living cells and zebrafishes. (C) 2018 Elsevier B.V. All rights reserved.
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