A BODIPY-based ratiometric probe for sensing and imaging hydrogen polysulfides in living cells

Hydrogen polysulfides (H2Sn, n>1) have attracted increasing attention in biological systems due to its redox signaling effect. To illustrate the process of the physiological and pathological roles played by H2Sn, accurate detection is highly desired. In this work, we report a BODIPY-based fluorescent probe (BDP-PHS) for ratiometric H2Sn sensing. BDP-PHS shows higher sensitivity and selectivity ratiometric response toward H2Sn than various biological related species. Moreover, BDP-PHS has been successfully applied in imaging of H2Sn in living cells. (C) 2019 Elsevier B.V. All rights reserved.