期刊
SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE
卷 15, 期 1, 页码 75-86出版社
OXFORD UNIV PRESS
DOI: 10.1093/scan/nsaa014
关键词
depression; orbitofrontal cortex; inferior frontal gyrus; functional connectivity; inhibition; reward; non-reward; impulsivity
资金
- 111 Project [B18015]
- key project of Shanghai Science Technology [16JC1420402]
- National Key R&D Program of China [2018YFC1312900, 2017YFA0505700]
- National Natural Science Foundation of China [NSFC 91630314, 31300917]
- Shanghai Municipal Science and Technology Major Project [2018SHZDZX01]
- National Natural Sciences Foundation of China [81701773, 11771010, 31271087, 31470981, 31571137, 31500885]
- Shanghai Sailing Program [17YF1426200]
- Research Fund for the Doctoral Program of Higher Education of China [2017M610226]
- Natural Science Foundation of Shanghai [18ZR1404400]
- ZJLab
- National Outstanding young people plan
- Program for the Top Young Talents by Chongqing
- Fundamental Research Funds for the Central Universities [SWU1509383]
- Natural Science Foundation of Chongqing [cstc2015jcyjA10106]
- General Financial Grant from the China Postdoctoral Science Foundation [2015M572423]
- Chongqing Research Program of Basic Research and Frontier Technology [cstc2016jcyjA0352]
The orbitofrontal cortex extends into the laterally adjacent inferior frontal gyrus. We analyzed how voxel-level functional connectivity of the inferior frontal gyrus and orbitofrontal cortex is related to depression in 282 people with major depressive disorder (125 were unmedicated) and 254 controls, using FDR correction P<0.05 for pairs of voxels. In the unmedicated group, higher functional connectivity was found of the right inferior frontal gyrus with voxels in the lateral and medial orbitofrontal cortex, cingulate cortex, temporal lobe, angular gyrus, precuneus, hippocampus and frontal gyri. In medicated patients, these functional connectivities were lower and toward those in controls. Functional connectivities between the lateral orbitofrontal cortex and the precuneus, posterior cingulate cortex, inferior frontal gyrus, ventromedial prefrontal cortex and the angular and middle frontal gyri were higher in unmedicated patients, and closer to controls in medicated patients. Medial orbitofrontal cortex voxels had lower functional connectivity with temporal cortex areas, the parahippocampal gyrus and fusiform gyrus, and medication did not result in these being closer to controls. These findings are consistent with the hypothesis that the orbitofrontal cortex is involved in depression, and can influence mood and behavior via the right inferior frontal gyrus, which projects to premotor cortical areas.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据