期刊
SMALL
卷 16, 期 7, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201906240
关键词
MDR bacteria; metal-organic frameworks; photodynamic therapy; titanium incorporation; wound healing
类别
资金
- National Key RAMP
- D Program of China [2018YFA0902600, 2017YFA0205901]
- National Natural Science Foundation of China [21535001, 81730051, 21761142006]
- Chinese Academy of Sciences [QYZDJ-SSW-SLH039, 121D11KYSB20170026, XDA16020902]
- Tencent Foundation through the XPLORER PRIZE
This study uses metal-organic frameworks (MOFs) alone without any added antibacterial ingredients as the nonantibiotic agent for photodynamic therapy (PDT) of chronic wounds infected by multidrug-resistant (MDR) bacteria. Nanoparticles (NPs) of MOFs (PCN-224) are incorporated with titanium through a facile cation exchange strategy. The obtained bimetallic PCN-224(Zr/Ti) shows greatly enhanced photocatalytic performance for the generation of reactive oxygen species under visible light, which is responsible for the effective antibacterial activities. The PCN-224(Zr/Ti) NPs are loaded onto lactic-co-glycolic acid nanofibers to prepare a wound dressing, which shows high biocompatibility and minimal cytotoxicity. The wound dressing is efficient for PDT-based in vivo healing of the chronic wound infected by MDR bacteria. Most importantly, this work does not involve any additional antibacterial agents, which is facile, low cost, and in particular, greatly explores the potential of MOFs as a powerful nonantibiotic agent in PDT.
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