期刊
SMALL
卷 16, 期 6, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201906436
关键词
bioelectronics; electrochemical biosensors; ion-selective electrodes; microfluidics
类别
资金
- Defense Advanced Research Projects Agency (DARPA), Army Research Office [W911NF-18-2-0104]
A balanced concentration of ions is essential for biological processes to occur. For example, [H+] gradients power adenosine triphosphate synthesis, dynamic changes in [K+] and [Na+] create action potentials in neuronal communication, and [Cl-] contributes to maintaining appropriate cell membrane voltage. Sensing ionic concentration is thus important for monitoring and regulating many biological processes. This work demonstrates an ion-selective microelectrode array that simultaneously and independently senses [K+], [Na+], and [Cl-] in electrolyte solutions. To obtain ion specificity, the required ion-selective membranes are patterned using microfluidics. As a proof of concept, the change in ionic concentration is monitored during cell proliferation in a cell culture medium. This microelectrode array can easily be integrated in lab-on-a-chip approaches to physiology and biological research and applications.
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