期刊
SMALL
卷 16, 期 4, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201902224
关键词
biomaterials; collagen; encapsulation; self-assembly; spray-drying
类别
资金
- French state funds by the Agence Nationale de la Recherche (ANR) [ANR-2010-RFCS-0006]
- French state funds within Investissements d'Avenir programme [ANR-11-IDEX-0004-02]
Extracellular matrices (ECM) rich in type I collagen exhibit characteristic anisotropic ultrastructures. Nevertheless, working in vitro with this biomacromolecule remains challenging. When processed, denaturation of the collagen molecule is easily induced in vitro avoiding proper fibril self-assembly and further hierarchical order. Here, an innovative approach enables the production of highly concentrated injectable collagen microparticles, based on collagen molecules self-assembly, thanks to the use of spray-drying process. The versatility of the process is shown by performing encapsulation of secretion products of gingival mesenchymal stem cells (gMSCs), which are chosen as a bioactive therapeutic product for their potential efficiency in stimulating the regeneration of a damaged ECM. The injection of collagen microparticles in a cell culture medium results in a locally organized fibrillar matrix. The efficiency of this approach for making easily handleable collagen microparticles for encapsulation and injection opens perspectives in active tissue regeneration and 3D bioprinted scaffolds.
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