期刊
CANCER CELL
卷 29, 期 4, 页码 587-601出版社
CELL PRESS
DOI: 10.1016/j.ccell.2016.03.005
关键词
-
资金
- Dietmar Hopp Foundation
- Helmholtz Alliance 'Immunotherapy of Cancer'
- IFB-Tx [BMBF 01EO1302]
- DFG [SFB738, KFO227]
- MEDSYS grant
- GERONTOSYS grant
The immune response influences the clinical course of colorectal cancer (CRC). Analyzing the invasive margin of human CRC liver metastases, we identified a mechanism of immune cell exploitation by tumor cells. While two distinct subsets of myeloid cells induce an influx of T cells into the invasive margin via CXCL9/CXCL10, CCL5 is produced by these T cells and stimulates pro-tumoral effects via CCR5. CCR5 blockade in patientderived functional in vitro organotypic culture models showed a macrophage repolarization with anti-tumoral effects. These anti-tumoral effects were then confirmed in a phase I trial with a CCR5 antagonist in patients with liver metastases of advanced refractory CRC. Mitigation of tumor-promoting inflammation within the tumor tissue and objective tumor responses in CRC were observed.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据