期刊
SENSORS AND ACTUATORS B-CHEMICAL
卷 303, 期 -, 页码 -出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2019.127284
关键词
Fluorescent probe; Benzothiazole derived; Peroxynitrite; Bioimaging; Mitochondria
资金
- National Natural Science Foundation of China [21575015, 21505004]
Peroxynitrite (ONOO-), an endogenous reactive oxygen species, acts an important role in various physiological and pathological processes. Herein, we designed a mitochondria targeting fluorescent probe MBTBE for sensitive determination of ONOO-. MBTBE exhibits rapid response ( < 1 min) and high selectivity towards peroxynitrite with distinct color changing (colorless to orange). The fluorescence intensity at 569 rim was linearly correlated with the concentration of ONOO- (0-10 mu M) with a detection limit of 16 nM. Additionally, MBTBE possesses good biocompatibility and mitochondria-targeting. Furthermore, MBTBE was successfully applied to monitor fluctuations in ONOO-levels and H2S-induced ONOO- clearing in HeLa cells, indicating excellent potential applications in bioanalysis analysis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据