4.6 Article

Nanocomposite Based on Poly (para-phenylene)/Chemical Reduced Graphene Oxide as a Platform for Simultaneous Detection of Ascorbic Acid, Dopamine and Uric Acid

期刊

SENSORS
卷 20, 期 5, 页码 -

出版社

MDPI
DOI: 10.3390/s20051256

关键词

nanocomposite; reduced graphene oxide; poly(paraphenylene); ascorbic acid; dopamine; uric acid; urine

资金

  1. Minister of Higher Education for Scientific Research of Tunisia
  2. MAE France for mobility project PHC Maghreb [39382RE]

向作者/读者索取更多资源

In this study, an efficient and simple designed nanohybrid created for individual and simultaneous detection of ascorbic acid (AA), dopamine (DA) and uric acid (UA). This nanohybrid is a combination of chemical reduced graphene oxide (CRGO) and redox poly(para-phenylene) (Fc-ac-PP) modified in a lateral position with ferrrocenyl group CRGO/Fc-ac-PPP. The CRGO/Fc-ac-PPP nanohybrid demonstrated a synergistic effect resulting in a large conductivity, surface area and catalytic properties provided by the redox attached ferrocene. Moreover, this nanocomposite is able to detect individually as well as simultaneously AA, DA and UA in a co-existence system with defined and separated redox peaks oxidation. The linear response ranges for AA, DA and UA, when detected simultaneously, are 0.1-10000 mu M, 0.0001-1000 mu M and 0.1-10000 mu M, respectively, and the detection limits (S/N = 3) are 0.046 mu M, 0.2 nM and 0.013 mu M, respectively. The proposed sensor shown satisfactory results when applied to real spiked urine samples for measuring the abnormal high or lowconcentration of AA, DA and UA in vivo.

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