期刊
SEMINARS IN CANCER BIOLOGY
卷 68, 期 -, 页码 186-191出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcancer.2020.01.008
关键词
Drug repurposing; Drug repositioning; Off-label; ReDO project
类别
Drug repurposing is a strategy to develop novel cancer treatments by reusing existing medicines developed in other disease areas. Key issues include candidate drug selection, clinical trial development, drug licensing/approval, and clinical adoption.
Drug repurposing is a strategy that aims to develop novel cancer treatments through the reuse of existing medicines developed in other disease areas. Such a strategy includes the identification of candidate drugs, clinical development, drug licensing, reimbursement and clinical implementation. This review outlines a literature-based approach to candidate selection with illustrative examples in osteosarcoma, pancreatic cancer and perioperative therapies. Key issues related to the development of clinical trials, drug licensing/approval and clinical adoption are explored to highlight some of the obstacles that must be overcome to successfully repurpose a drug as a new therapeutic option.
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