期刊
CANCER BIOMARKERS
卷 16, 期 1, 页码 55-64出版社
IOS PRESS
DOI: 10.3233/CBM-150540
关键词
Cancer; HNSCC; miRNA profile; qRT-PCR; biomarker
类别
资金
- Committee of Scientific Researches (KBN) Poland [1869/B/P01/2008/34]
- National Science Center [2011/01/B/NZ5/02773]
- National Institute on Aging of the National Institutes of Health [R01AG032290]
- NATIONAL INSTITUTE ON AGING [R01AG032290] Funding Source: NIH RePORTER
BACKGROUND: The necessity of prediction and treatment outcome improvement of HNSCC needs to find new biomarkers. miRNAs seem to be good candidate for that. OBJECTIVE: Analysis of selected 5 miRNAs (let-7d, miR-18a, miR-21, miR-205 and miR-375) as potential biomarkers that allows to distinguish tumor and healthy tissue taken from HNSCC patients. METHODS: Tumor and normal epithelial tissues were obtained from 75 HNSCC patients to analyze selected miRNAs. RESULTS: Analysis indicated significant increase of miR-21 and miR-205 in tumor when compared with healthy tissue (p = 0.0069 and p = 0.0029, respectively). There was a significant correlation between let-7d and miR-18a. let-7d was down-regulated in 34.67% cases, miR-18a in 29.33%, miR-21 in 20%, miR-205 in 30.67% and miR-375 in 52% cases. At the same time overexpression of let-7d was detected in 18.67% cases, miR-18a in 22.67%, miR-21 in 48%, miR-205 in 41.33% and miR-375 in 52% cases. There was no correlation between miRNA expression and clinical data and the course of illness. CONCLUSION: Our study indicated that miR-21 and miR-205 can be used to analyze the clarity of surgical margins and that concomitant changes in the expression of let-7 and miR-18a in tumor tissues might represent important future markers indicating the biology of HNSCC. These observations will help with developing personalization for HNSCC patients' treatment.
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