期刊
CANCER BIOLOGY & THERAPY
卷 17, 期 9, 页码 899-910出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/15384047.2016.1210732
关键词
Apoptosis; cancer; ferroptosis; necroptosis; necrosis; pyroptosis
类别
资金
- University of the Witwatersrand Post Graduate Merit Award
- Claude Leon Harris Honors Scholarship Program bursary
- RNA Therapeutics Research Group Bursary Scheme
This review embarks upon a cell death journey from the discovery of apoptosis and necrosis through to the coalescence of these: necroptosis. The mechanisms of 2 emerging necrotic cell death pathways, pyroptosis and ferroptosis, will be explored before delving into apoptotic and necroptotic signaling cascades, highlighting the complex interplay between molecular players. The involvement of the ripoptosome, interferon signaling and DNA damage in necroptosis will be discussed briefly. The major focus is on necroptosis initiation by tumor necrosis factor- (TNF) and its cognate receptor TNFR1, caspase-independent RIP1/RIP3/MLKL necrosome activation and cell death propagation by damage-associated molecular pattern (DAMP) release. Finally, the implications of a complex cell death signaling network will be revealed in the context of cancer biology and therapy. The clinical contribution of the discovery of necroptosis as an unequivocally new way of dying is monumental and could drastically alter cancer therapy strategies in the future.
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