期刊
CANCER AND METASTASIS REVIEWS
卷 35, 期 4, 页码 515-524出版社
SPRINGER
DOI: 10.1007/s10555-016-9637-x
关键词
PI3K; AKT; mTOR; Breast cancer
类别
Anti-cancer cancer-targeted therapies are designed to exploit a particular vulnerability in the tumor, which in most cases results from its dependence on an oncogene and/or loss of a tumor suppressor. Mutations in the phosphoinositide 3-kinase (PI3K)/AKT/mTOR pathway are freqcuently found in breast cancers and associated with cellular transformation, tumorigenesis, cancer progression, and drug resistance. Several drugs targeting PI3K/ATK/mTOR are currently in clinical trials, mainly in combination with endocrine therapy and anti-HER2 therapy. These drugs are the focus of this review.
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