期刊
SCIENCE
卷 367, 期 6481, 页码 1021-+出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aba2419
关键词
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资金
- EPSRC [EP/P004997/1]
- European Research Council [758427]
- EPSRC [EP/P004997/1] Funding Source: UKRI
- European Research Council (ERC) [758427] Funding Source: European Research Council (ERC)
Organic halides are important building blocks in synthesis, but their use in (photo)redox chemistry is limited by their low reduction potentials. Halogen-atom transfer remains the most reliable approach to exploit these substrates in radical processes despite its requirement for hazardous reagents and initiators such as tributyltin hydride. In this study, we demonstrate that alpha-aminoalkyl radicals, easily accessible from simple amines, promote the homolytic activation of carbon-halogen bonds with a reactivity profile mirroring that of classical tin radicals. This strategy conveniently engages alkyl and aryl halides in a wide range of redox transformations to construct sp(3)-sp(3), sp(3)-sp(2), and sp(2)-sp(2) carbon-carbon bonds under mild conditions with high chemoselectivity.
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