4.6 Article

Elevated Extracellular Free-Water in a Multicentric First-Episode Psychosis Sample, Decrease During the First 2 Years of Illness

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Extracellular free water and glutathione in first-episode psychosis-a multimodal investigation of an inflammatory model for psychosis

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Summary: This study found that patients with first-episode schizophrenia have significantly increased extracellular free water (FW) in the gray matter of the brain, while levels of glutathione (GSH) showed no significant difference. In patients with schizophrenia, there was a significant negative correlation between DLPFC GSH and both whole-brain and DLPFC-specific gray matter FW.

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