4.2 Article

Tumour-associated B cells in urothelial urinary bladder cancer

期刊

SCANDINAVIAN JOURNAL OF IMMUNOLOGY
卷 91, 期 2, 页码 -

出版社

WILEY
DOI: 10.1111/sji.12830

关键词

follicle-like structures; tumour-associated B cells; urinary bladder cancer

资金

  1. Swedish Cancer Foundation
  2. IMTAC
  3. Swedish Research Council
  4. Cancer Research Foundation
  5. Wallenberg Foundation

向作者/读者索取更多资源

Tumour infiltrating B cells and CD38(+) plasma cells have been correlated with survival in different malignancies but their role in urinary bladder cancer is unclear. IL-10 is a multifunctional cytokine with both anti-inflammatory and immunostimulatory properties, that can be released by regulatory B cells (Bregs). We have stained paraffin-embedded tumour sections from 31 patients with invasive urothelial urinary bladder cancer with respect to CD20(+) B cells, CD38(+) cells, IL-10-expressing cells, IgG, C1q and C3a and analysed the impact of these markers on survival. Interestingly, we observe tumour-associated CD20(+) B cells forming follicle-like structures in tumours of some patients. We demonstrate that follicle-like structures, tumour-associated CD38(+) cells, IL-10 produced by non-B cells, tumour infiltrating IgG and activation of the complement system, may associate to longer survival of urinary bladder cancer patients. IL-10 expression by tumour-associated Bregs may instead negatively affect prognosis. More research is needed to fully understand the role of B cells and IL-10 in urinary bladder cancer.

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