期刊
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
卷 91, 期 2, 页码 -出版社
WILEY
DOI: 10.1111/sji.12830
关键词
follicle-like structures; tumour-associated B cells; urinary bladder cancer
类别
资金
- Swedish Cancer Foundation
- IMTAC
- Swedish Research Council
- Cancer Research Foundation
- Wallenberg Foundation
Tumour infiltrating B cells and CD38(+) plasma cells have been correlated with survival in different malignancies but their role in urinary bladder cancer is unclear. IL-10 is a multifunctional cytokine with both anti-inflammatory and immunostimulatory properties, that can be released by regulatory B cells (Bregs). We have stained paraffin-embedded tumour sections from 31 patients with invasive urothelial urinary bladder cancer with respect to CD20(+) B cells, CD38(+) cells, IL-10-expressing cells, IgG, C1q and C3a and analysed the impact of these markers on survival. Interestingly, we observe tumour-associated CD20(+) B cells forming follicle-like structures in tumours of some patients. We demonstrate that follicle-like structures, tumour-associated CD38(+) cells, IL-10 produced by non-B cells, tumour infiltrating IgG and activation of the complement system, may associate to longer survival of urinary bladder cancer patients. IL-10 expression by tumour-associated Bregs may instead negatively affect prognosis. More research is needed to fully understand the role of B cells and IL-10 in urinary bladder cancer.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据