期刊
SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION
卷 80, 期 2, 页码 129-132出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/00365513.2019.1703211
关键词
Hydrops fetalis syndrome; Hb Bart's disease; capillary electrophoresis (CE); thalassemia
资金
- Health Department Research Fund of Guangxi [Z2011449]
- Key Research and Development Program of Guangxi [AB17292089]
Hydrops fetalis syndrome (Hb Bart's disease) is one of the common fetal development abnormalities and the most severe form of alpha-thalassemia. It causes fetal death during the third trimester or shortly after birth. The aim of this study is to investigate the feature of Hb Bart's disease by Capillary electrophoresis (CE) and its genotypes. A total of 38 cases of suspected fetal Hb Bart's disease were analyzed by B-ultrasound and CE, including 17 with 24-28 weeks of pregnancy, 9 with 29-32 weeks of pregnancy, and 12 with 33-38 weeks of pregnancy. All cases were then identified by DNA analysis. The minimum concentration of Hb Bart's was 72.2% and the highest 90.9%. Hb Bart's fraction increased while that of Hb Portland decreased with the duration of pregnancy. In order to avoid serious maternal morbidity, it is necessary to diagnose Hb Bart's disease as soon as possible and CE can be used as a method of rapid diagnosis.
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